Cannabis: Our Natural Ally Against Cancer, Inflammation, and Aging
I have written about the extraordinary healing benefits of cannabis, including her ability to cure cancer in many people here. In this blog piece I’ve provided some updated studies regarding cannabis and cancer, including skin cancers. Plus, given how effective the anti-cancer, antioxidant and anti-inflammatory properties of cannabis have been in fighting cancer, you might imagine the benefits this plant also holds for our skin as we confront the ravages of toxins, UV exposure and aging skin! And indeed, the research has borne that out.
The first half of this piece provides anecdotal evidence and scientific studies establishing again and again how cannabis has been able to heal the infliction we call cancer. The second half provides more studies, many of which are built off the cancer studies, showing how cannabinoids can not only protect our skin from cancer, but can also protect our skin before we get cancer- promoting skin rejuvenation, providing protection from the sun, stimulating the production of collagen, improving skin elasticity and reducing the appearance of wrinkles.
This piece took me awhile to pull together but it’s truly inspirational stuff and each time I travel down these rabbit holes I get excited all over again. The redundancy or repetition of concepts is intentional since I know some of you will only read the section about how cannabis can give you younger looking skin or protect you from too much sun or the section about treating skin cancer or the wonderful testimonials of how cannabis cured all sorts of cancers. I share this with you for your benefit with love and on behalf of the plant.
Anecdotal Reports of Rick Simpson Oil (RSO) Curing Cancer
I focus on Rick Simpson Oil (RSO)1 here because that’s the very concentrated form of cannabis oil that one needs to obtain the results you’re about to read about.
A sample of testimonials:
Stage 4 Kidney Cancer
Diagnosed with stage 4 kidney cancer, with a tumor the size of a grapefruit, Jim began using Rick Simpson Oil. His tumor shrank and eventually he became cancer-free. [2]
Hodgkin's Lymphoma
A patient with an 11-year history of Hodgkin's lymphoma chose RSO after conventional treatments failed. Within five months, his tumors disappeared, and he was declared cancer-free. [3]
Breast Cancer
Linda used RSO to treat her aggressive breast cancer. Within five weeks, her tumor shrank significantly, allowing her to avoid chemotherapy [4].
Stage 4 Throat Cancer
Greg, a U.S. Marine veteran, was diagnosed with stage 4 throat cancer. After undergoing chemotherapy and radiation, he began using RSO. Within two weeks, he reported increased energy and improved well-being. Today, Greg has been cancer-free for five years. [5]
Anal Canal Cancer
Corrie was diagnosed with anal canal cancer and had two spots of skin cancer. Choosing to forgo radiation, she used RSO both topically and orally. Within weeks, her skin lesions disappeared, and subsequent scans showed no signs of cancer. [6]
Recurrent Cancer
Facing her third cancer recurrence, Stefanie LaRue opted for RSO over chemotherapy. Following the RSO protocol, she became cancer-free, with her doctor acknowledging the effectiveness of the treatment. [7]
Squamous Cell Carcinoma
Michael McShane treated his skin cancer topically with RSO. Over three months, the cancerous lesion broke down and was replaced by healthy skin. [8]
Basal Cell Carcinoma
An individual treated basal cell carcinoma with cannabis oil over 35 days. Photographic evidence showed the lesion healing progressively, leading to a complete recovery. [9]
There are thousands more inspirational stories of people who have overcome their cancers. You can see a few hundred more at Cannabis Health Radio Podcast and at Rick Simpson’s original site, Phoenix Tears, and at Rick Simpson Oil California https://phoenixtears.ca/testimonials/ and you can check out Cannabis Success Stories on Facebook and talk to people there if you choose. In addition to these real-life testimonies there are a myriad of scientific reports, which are referenced in my blogs and I’ve included a few more here, for those who want to read more.
Scientific Studies Demonstrating Cannabis Kills and Stops Tumor Growth
An ever-increasing number of studies demonstrate how cannabinoids like THC and CBD trigger apoptosis (apoptosis is programmed cell death, meaning the cannabinoids cause cancer cells to self-destruct without harming surrounding healthy tissue). The anti-inflammatory and antioxidant properties of cannabinoids have been shown to inhibit and reduce tumor growth, stop the formation of new blood vessels (angiogenesis), and suppress chronic inflammation - which is often linked to cancer development and progression. Moreover, by reducing inflammation, cannabinoids further hinder tumor growth since chronic inflammation can fuel cancer cells to proliferate.
This recent review (2023), Cannabis and cancer: unveiling the potential of a green ally in breast, colorectal, and prostate [10] analyzed and summarized the growing body of evidence regarding cannabis compounds’ successful use in three major cancer types: breast, colorectal (colon), and prostate cancer. Both THC and CBD were shown to inhibit cancer cell growth, induce apoptosis in cancer cells and reduce metastasis.
In this recent compilation of studies, Cannabidiol (CBD) in Cancer Management, [11] CBD was found to inhibit tumor growth, trigger apoptosis of cancer cells, possess anti metastatic effects, as well as managing pain and neuropathy, nausea and vomiting, anxiety and depression and sleep disturbance. The specific cancers where these benefits were observed included breast cancer, prostate cancer, colorectal cancer, Glioblastoma (brain cancer), lung cancer, pancreatic cancer, leukemia, melanoma (skin cancer), neuroblastoma.
Colon Cancer
A 2023 study published in Genes & Genomics explored THC's effects on human colorectal (colon) cancer cells. [12] Researchers found that THC can kill colorectal cancer cells by triggering specific types of cell death. The THC inhibited cell proliferation and induced apoptosis as well as disrupting cancer cell viability through multiple mechanisms.
Brain Cancer
Beyond promoting cell death THC also exhibits anti-tumor properties, as demonstrated in this study where THC was shown to reduce tumor growth in animal models of cancer, particularly in glioblastoma multiforme, one of the most aggressive forms of brain cancer. [13] The study emphasized that THC not only inhibited tumor growth but also reduced the spread of cancer cells (metastasis).
Prostate Cancer
In this 2023 study [14] CBD was found to be effective against prostate cancer. The CBD slowed the growth of the prostate cancer cells and caused cell death (apoptosis) in the cancer cells.
Breast Cancer
Research has shown that different cannabinoids can have varying effects depending on the breast cancer subtype. These are those findings from Cannabinoids in Breast Cancer: Differential Susceptibility According to Subtype (2021) [15]:
- Triple-Negative Breast Cancer (TNBC): CBD was found to reduce cell proliferation and induce apoptosis in TNBC cells. Moreover, CBD reduced tumor cell growth, increased oxidative stress, promoted both apoptosis and autophagy (autophagy, meaning "self-eating," is a cellular process where cells break down and recycle damaged or unused components to maintain cellular health and energy balance) while simultaneously inhibiting metastasis.
- HER2-Positive Breast Cancer: THC reduced tumor growth and metastasis by inducing apoptosis and inhibiting angiogenesis (formation of new blood vessels that feed tumors).
- Estrogen Receptor-Positive (ER+) Breast Cancer: CBD and THC inhibited cell proliferation and induced apoptosis.
Bladder cancer
A 2023 study [16] published in the Journal of Cannabis Research, revealed that both THC and CBD induced apoptosis in bladder cancer cells. Researchers also found the effects of the chemotherapeutic drugs were enhanced by the THC/CBD. [17]
Lung cancer
The conclusion from several studies indicates both THC and CBD have been successful in inhibiting lung cancer cell growth and metastasis through different mechanisms. THC primarily acts to reduce cell proliferation and migration, while CBD induces cell death, inhibits invasion, and seems to overcome chemotherapy resistance. The combination of THC and CBD enables the synergistic effects. [18]
Breast Cancer
A 2020 study [19] investigated the effects of a combination of cannabinoids including THC and CBD (also CBG and CBN). The combination led to induced apoptosis (programmed cell death) with minimal or no toxicity on non-cancerous breast cells.
Bile Duct Cancer
A 2024 study [20] published in BMC Complementary Medicine and Therapies found that CBD induced apoptosis and suppressed tumor growth in Bile Duct Cancer.
Brain Cancer
A 2009 study [21] conducted by researchers at the Complutense University of Madrid found that THC induces the death of brain cancer cells by activating specific signaling pathways, without damaging surrounding healthy tissue.
Scientific Studies Demonstrating Cannabis’s Potential to Cure Cancer- Specifically in Skin Cancers
In addition to inducing cell death (apoptosis), blocking cancer cell growth and stopping the formation of new blood vessels (angiogenesis) - which vessels are necessary for tumors to grow - cannabis’s anti-inflammatory properties suppress chronic inflammation, which is often linked to cancer development and progression.
THC and CBD were also found to increase oxidative stress. This is helpful because cancer cells grow very fast and use a lot of energy. This fast growth already puts the cancer cells under a lot of oxidative stress—a state where harmful molecules (free radicals, i.e., unstable molecules that age the skin) accumulate and damage the cells. In essence, the cannabinoids push already stressed cancer cells to a breaking point, triggering their self-destruction, while sparing healthy cells.
Here are a few studies regarding cannabis and skin cancers:
Squamous Cell Carcinoma
A 2021 case report [22] documented an 80-year-old women with squamous cell carcinoma on her shin who applied THC-rich oil topically for four weeks instead of undergoing surgery or chemotherapy. At a 14-month follow-up, the lesion had regressed to a benign state, and three years later, no recurrence was observed.
Melanoma
In this study, [23] THC and CBD were shown to work synergistically to reduce tumor size and slow the spread of melanoma cells. THC reduced the tumor size and triggered apoptosis (programmed cell death) in melanoma cells while CBD inhibited cancer cell proliferation and reduced metastasis (the spread of cancer to other parts of the body). It also had anti-inflammatory and antioxidant effects, which are necessary in cancer control. Some studies reported that using THC and CBD together had a greater effect than using either compound alone. This is the synergistic effect that scientists refer to as the entourage effect.
Basal Cell Carcinoma
A 74-year-old man with recurrent Basal Cell Carcinoma on his nose, had had multiple surgical interventions over 13 years. This time he applied a topical preparation of THC 4 times daily for two weeks. The malignant lesion completely disappeared within this period. [24]
Squamous Cell Carcinoma
In this 2022 study [25] a 64-year-old woman with a history of multiple skin cancers developed two new skin lesions. Both lesions were cured within 4 weeks using a topical CBD concentrated oil twice/day.
Melanoma
This study [26] found that a cannabis extract made up of various cannabinoids, of which 60% was CBD, could decrease the viability of melanoma cells, hinder tumor growth, and help prevent the spread of cancer. The study also noted that when the CBD was given in an isolated way- without the other cannabinoids- it exhibited less potent effects, highlighting what we all know- the enhanced efficacy of whole plant medicine.
Squamous cell carcinoma
A 2022 research review [27] found that cannabinoids, including THC and CBD, have anti tumor effects on squamous cell carcinoma. The cannabinoids were shown to trigger apoptosis and slow down or stop tumor growth (the cannabinoids impacted the tumors by cutting off the blood supply to the tumors).
Head and neck squamous cell carcinoma
A 2023 study [28] analyzed the effects of 24 cannabis extracts on head and neck squamous cell carcinoma and found that CBD-rich extracts were the most effective in inducing cancer cell death The strongest results came from CBD combined with THC in a 2:1 ratio.
Basal Cell & Squamous Cell Carcinoma
In this study [29] researchers found the cannabis slowed down the growth of cancerous skin tumors and also reduced the number of blood vessels feeding the tumors (angiogenesis) causing cancer cells to die without harming healthy skin cells.
Melanoma
This study [30] investigated the impact of a cannabis extract on melanoma cells, both alone and in combination with radiation. Researchers found the cannabis extract alone significantly reduced melanoma cell viability and proliferation. The melanoma cells in this study were found to be resistant to radiation.
Squamous Cell Carcinoma
In this 2022 study [31] a 64-year-old woman with a history of multiple skin cancers developed two new skin lesions. Both lesions were cured within 4 weeks using a topical CBD concentrated oil twice/day. These are pictures from that report- the first pictures are of squamous cell carcinoma. The second set of pictures turned out not to be cancerous, but rather Lichen simplex chronicus (known as neurodermatitis, it’s a skin condition caused by chronic itching and scratching, leading to thickened, leathery, and sometimes darker skin patches).
Resolved squamous cell carcinoma on the right hand.
Distant (a) and closer (b) views of an erythematous patch (black oval) with a small focus of scale (black arrow) on the lateral right dorsal hand representing the treated site of a biopsy-confirmed squamous cell carcinoma that completely resolved with twice daily application of CBD oil for four weeks.
Lichen simplex chronicus on the left dorsal hand.
Distant (a) and closer (b) views of a red scaly plaque (black oval) on the left dorsal hand. Skin biopsy established a diagnosis of lichen simplex chronicus, which completely resolved within four weeks after starting twice-daily topical treatment with 20% cannabinoid oil.
Before receiving the pathology report, she began topical treatment of the lesion with a CBD oil. She applied the CBD oil twice daily to the lesion. Within four weeks, the lesion site only showed erythema (that’s redness of the skin).
Anti-Aging and Other Benefits of Cannabis for the Skin
The very same antioxidant and anti-inflammatory properties of cannabinoids which have been successful in defeating all types of cancer, have also been shown to protect the skin from environmental stress like pollution and UV radiation, both of which contribute to skin aging. Inflammation is another key driver of skin aging as it can damage collagen and elastin, leading to wrinkles and sagging skin.
However, as the studies regarding cancer as well as the studies below demonstrate, THC and CBD can promote skin cell rejuvenation, enhance wound healing, and reduce the appearance of wrinkles by combatting oxidative stress. [32]
The antioxidants from cannabis help protect the skin from free radical damage which can accelerate the aging process and contribute to wrinkles. Research further suggests that the cannabinoids may stimulate the production of collagen and elastin, two proteins crucial for skin firmness and elasticity. By promoting these proteins, cannabis can help improve skin elasticity as well as reduce the appearance of wrinkles. The compounds in cannabis can also help prevent skin dehydration, which also contributes to wrinkles.
Scientific Findings on Cannabis and Skin Aging
THC and CBD Rejuvenated Aging Skin Cells
This 2022 study, entitled Phytocannabinoids Stimulate Rejuvenation and Prevent Cellular Senescence in Human Dermal Fibroblasts, [33] investigated how THC and CBD affect human skin cells, particularly focusing on their potential anti-aging properties. Researchers demonstrated that both cannabinoids can stimulate human dermal fibroblasts (the most common type of cells found in connective tissue - they produce and maintain the cell matrix, including collagen, which provides structural support to tissues). Both THC and CBD were found to play a crucial role in wound healing and tissue repair by creating the framework for new tissue formation.
The study found the cannabinoids’ ability to stimulate these fibroblast cells led to increased cell proliferation in healthy but aging cells, reduced markers of cellular aging, and enhanced wound healing. Additionally, the THC and CBD increased the level of genes responsible for producing collagen, elastin, and hyaluronic acid—key components for maintaining skin elasticity and reducing wrinkles. The level of wrinkle related genes was decreased, suggesting that cannabinoids by themselves may slow skin aging or even reverse some signs.
Low levels of CBD and THC Protect Collagen, Reduce Inflammation and Slow Aging
In this study, Anti-Aging Properties of Cannabis sativa Leaf Extract against UVA Irradiation, [34] scientists, explored the anti-aging properties of cannabis, using the leaves of a hemp plant (containing lower levels of CBD and even lower THC). They found that the antioxidant properties of the cannabis leaf extract helped to prevent damage from sun exposure and support skin cell health. Specifically, they found the cannabis protected collagen (which keeps skin firm), reduced inflammation and slowed cell aging.
The researchers concluded that the properties derived from these leaves could potentially prevent and/or treat photoaging (photoaging is premature skin aging caused by prolonged exposure to ultraviolet (UV) radiation from the sun or artificial sources). When skin cells were treated with the cannabis extract before UVA exposure, they showed less damage, lower levels of inflammation and less collagen breakdown.
THC and CBD Successfully Fight Free Radicals Thereby Preventing Skin Aging
In another study [35] scientists proved that both THC and CBD, as natural antioxidants, can effectively fight free radicals which is key to preventing skin aging.
CBD can Protect Skin from the Harmful Effects of Sun Exposure
A clinical study [36] involving 19 participants, published in the Journal of the American Academy of Dermatology, [37] found that topical application of CBD reduced UV-induced redness, DNA damage, and cellular harm. The protective benefits of CBD were apparent after 2 weeks of UV exposure: the CBD-treated skin showing less redness, less DNA damage and less cellular damage compared to the placebo. Since DNA damage can lead to mutations and rapid growth, resulting in skin cancer, this bodes well for cannabis’s ability to prophylactically reduce the risk of skin cancer.
The Protective Role of the Endocannabinoid System in Dermatology in General
As always, we return to our Endocannabinoid System to understand how cannabinoids can heal so well. In the afore cited study, Impact of Cannabinoid Compounds on Skin Cancer, the authors wrote: “The great importance of cannabinoid receptors for the homeostasis of the skin was clarified in a comprehensive study that demonstrated an involvement of these receptors in the pathogenesis of allergic contact dermatitis.” This study [38] established the protective role of the system in controlling skin rashes.
Psoriasis, Eczema Acne, Allergic reactions, Rosacea, Chronic inflammatory skin disease, Wound healing and Scars Benefit from Cannabis
The review entitled, Cannabis-Based Products for the Treatment of Skin Inflammatory Diseases [39] discusses how cannabis can help manage various skin conditions, particularly those involving inflammation. These conditions included psoriasis, eczema (atopic dermatitis), acne, contact dermatitis (allergic reactions), rosacea, chronic inflammatory skin disease, wound healing and scars may assist with skin regeneration and help in wound healing (by promoting cell growth and reducing inflammation, which could lead to faster recovery and better skin repair). Researchers noted these benefits are due to the cannabinoids interacting with the body's endocannabinoid system, which plays a role in regulating various skin functions, including inflammation and immune response.
CBD’s Benefits in Skin Aging, Acne, Wound Healing, Skin Regeneration
Published in the American Journal of Clinical Dermatology in October 2024, this study [40] explored the benefits of CBD for skin health and reiterated much of the findings of the studies herein. CBD has anti-aging and anti-inflammatory effects and can reduce inflammation and oxidative stress in the skin. The review also noted that topical application of CBD has been shown to increase skin hydration and elasticity by enhancing the expression of certain proteins involved in skin moisture retention. The findings of the other studies included here noted CBD’s ability to reduce acne, promote wound healing by reducing inflammation and supporting skin regeneration, and protect against UV-induced skin damage and DNA mutations.
Anti-inflammatory Property of THC Reduces Allergic Reaction
In this study [41] it was shown that the anti-inflammatory activity of THC, topically applied to an allergic swollen ear, reduced the allergic inflammation.
In Conclusion
Reading through all these studies one sees that sometimes only CBD is being touted for its wonderous anti-cancer and/or skin protective properties. Not surprisingly, there is a growing body of evidence suggesting that CBD may offer more potent anti-cancer effects than THC. But that may be a built-in prejudice wherein science is drawn to non intoxicating and federally legal substances like CBD. We used to believe it was mostly the THC that was needed to fight cancer or signs of aging, but perhaps that’s changing? Reading closely, you’ll see that many studies reiterate the wisdom that it’s the synergy of CBD and THC (plus sometimes other cannabinoids) working together which provides the greatest benefit for healing. Many of the studies have made that explicit finding.
As always, it’s best to work with as many different cannabinoids as possible because truth is - we don’t know what most of those over 100 cannabinoids grown by a plant actually do. Most of those cannabinoids are as of now unidentified and scientists tend to focus on just a few of the cannabinoids that we do know about. But they still recognize what they call “the entourage effect” which is the enhanced power from the synergy of the cannabinoids working together. And we know the plant’s wisdom is to be respected, which means all the cannabinoids she grows- the whole plant - is what we need to heal our bodies, our skin, and our souls.
1 Rick Simpson Oil (RSO) is the highly concentrated form of cannabis known in the market as FECO (Full extract cannabis oil). I still call it RSO after the man who resolved his skin cancer using this concentrated oil. I’ve been making it long before the name FECO came along, and I’ve always made it with organic cane alcohol.
2 unitedpatientsgroup.com+5Submit My Press Release+5cannabiscure.info+5
3 cureyourowncancer.org This site is still provided by searching Chat GPT, but the algorithms of the internet have quite unfortunately disappeared this site. It was an incredibly informative and reliable site that I’ve been visiting for more than a decade. I am very familiar with the Cure Your Own Cancer site and have read many testimonials there. Google’s AI says the site is no longer maintained. ChatGPT says it’s still active and will provide citation to it, but if you go to any of the links, you can’t get there. This is the current state of control over information that puts profit over and at the expense of people. The name of the cite says it all.
4 ricksimpsonoilcal.com+1phoenixtears.ca+1.
5 ricksimpsonoilcalifornia.com+1cannabiscure.info+1
6 cureyourowncancer.org This site is still provided by searching Chat GPT, but the algorithms of the internet have quite unfortunately disappeared this site. It was an incredibly informative and reliable site that I’ve been visiting for more than a decade. I am very familiar with the Cure Your Own Cancer site and have read many testimonials there. Google’s AI says the site is no longer maintained. ChatGPT says it’s still active and will provide citation to it, but if you go to any of the links, you can’t get there. This is the current state of control over information that puts profit over and at the expense of people. The name of the cite says it all.
7 Medical marijuana as the new herbalism, part 3: A “cannabis cures cancer” testimonial, Science-Based Medicine
8 cureyourowncancer.org This site is still provided by searching Chat GPT, but the algorithms of the internet have quite unfortunately disappeared this site. It was an incredibly informative and reliable site that I’ve been visiting for more than a decade. I am very familiar with the Cure Your Own Cancer site and have read many testimonials there. Google’s AI says the site is no longer maintained. ChatGPT says it’s still active and will provide citation to it, but if you go to any of the links, you can’t get there. This is the current state of control over information that puts profit over and at the expense of people. The name of the cite says it all.
9 cureyourowncancer.org+1phoenixtears.ca+1 This site is still provided by searching Chat GPT, but the algorithms of the internet have quite unfortunately disappeared this site. It was an incredibly informative and reliable site that I’ve been visiting for more than a decade. I am very familiar with the Cure Your Own Cancer site and have read many testimonials there. Google’s AI says the site is no longer maintained. ChatGPT says it’s still active and will provide citation to it, but if you go to any of the links, you can’t get there. This is the current state of control over information that puts profit over and at the expense of people. The name of the cite says it all.
10 Cannabis and cancer: unveiling the potential of a green ally in breast, colorectal, and prostate, https://pubmed.ncbi.nlm.nih.gov/38755733/
11Cannabidiol (CBD) in Cancer Management, PMC+1AACR Journals+1
12 Cell death induction and intracellular vesicle formation in human colorectal cancer cells treated with Δ9-Tetrahydrocannabinol, https://link.springer.com/article/10.1007/s13258-023- 01466-7
13 Anticancer mechanisms of cannabinoids,
14 Anti-proliferative effect of Cannabidiol in Prostate cancer cell PC3 is mediated by apoptotic cell death, NFκB activation, increased oxidative stress, and lower reduced glutathione status, https://pmc.ncbi.nlm.nih.gov/articles/PMC10553363/
15 Cannabinoids in Breast Cancer: Differential Susceptibility According to Subtype (2021), https://pubmed.ncbi.nlm.nih.gov/35011388/
16 Anticancer properties of cannabidiol and Δ9-tetrahydrocannabinol and synergistic effects with gemcitabine and cisplatin in bladder cancer cell lines,
https://jcannabisresearch.biomedcentral.com/articles/10.1186/s42238-023-00174-z
17 There are other cases wherein the impact of cannabinoids had increased beneficial effects of the conventional chemotherapy drugs being used. See for eg. this study, Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis,
https://pmc.ncbi.nlm.nih.gov/articles/PMC7409346/?utm_source=chatgpt.com wherein CBD reduced tumor growth and metastasis in breast cancer and when combined with chemotherapeutic drugs, exhibited synergistic antiproliferative effects. See also, Anti-Cancer Potential of Cannabinoids, Terpenes, and Flavonoids Present in Cannabis,
https://pmc.ncbi.nlm.nih.gov/articles/PMC7409346/?utm_source=chatgpt.com wherein CBD inhibited the growth of various prostate cancer cell lines by inducing apoptosis and additionally, CBD enhanced the effects of the pharmecutical drugs used.
18 Delta9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo, https://pubmed.ncbi.nlm.nih.gov/17621270/; Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1, https://pubmed.ncbi.nlm.nih.gov/22198381/; Cannabidiol Induces Cell Death in Human Lung Cancer Cells and Cancer Stem Cells, https://pubmed.ncbi.nlm.nih.gov/34832951/
19 Cannabinoid Combination Induces Cytoplasmic Vacuolation in MCF-7 Breast Cancer Cells (2020), https://pubmed.ncbi.nlm.nih.gov/33066359/
20 Cannabidiol exhibits potent anti-cancer activity against gemcitabine-resistant cholangiocarcinoma via ER-stress induction in vitro and in vivo, NCBI+2BioMed Central+2PubMed+2
21 Towards evidence based emergency medicine: Best BETs from the Manchester Royal Infirmary, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793545/.
22 Case Report: Squamous Cell Carcinoma and THC-Rich Cannabinoid Oil, https://www.endocannabinoidmedicine.com/academicarticle/squamous-cell-carcinoma-and-thc rich-cannabinoid-oil/
23 Roles of Cannabinoids in Melanoma: Evidence from In Vivo Studies, https://pubmed.ncbi.nlm.nih.gov/32839414/
24 Treatment of malignant diseases with phytocannabinoids: promising observations in animal models and patients, https://www.explorationpub.com/Journals/em/Article/1001182
25 Topical CBD Preparation Resolves Skin Cancer Lesions,
26 In Vitro Antiproliferative Effect of Cannabis Extract PHEC-66 on Melanoma Cell Lines, ResearchGate+2PMC+2PubMed+2
27 Impact of Cannabinoid Compounds on Skin Cancer, https://www.mdpi.com/2072- 6694/14/7/1769
28 The Effect of Cannabis Plant Extracts on Head and Neck Squamous Cell Carcinoma and the Quest for Cannabis-Based Personalized Therapy. https://www.mdpi.com/2072-6694/15/2/497
29 Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors, https://pubmed.ncbi.nlm.nih.gov/12511587/
30 Effects of Standardized Cannabis sativa Extract and Ionizing Radiation in Melanoma Cells In Vitro, PubMed+1Lippincott Journals+1
31 Topical CBD Preparation Resolves Skin Cancer Lesions,
32 Phytocannabinoids Stimulate Rejuvenation and Prevent Cellular Senescence in Human Dermal Fibroblasts, https://pubmed.ncbi.nlm.nih.gov/36497198/.
33 Phytocannabinoids Stimulate Rejuvenation and Prevent Cellular Senescence in Human Dermal Fibroblasts, (2022) https://pubmed.ncbi.nlm.nih.gov/36497198/
34 Anti-Aging Properties of Cannabis sativa Leaf Extract against UVA Irradiation. https://www.mdpi.com/2079-9284/11/2/45
35 Neuroprotective antioxidants from marijuana, https://pubmed.ncbi.nlm.nih.gov/10863546/
36 See also, CBD Skin Care May Protect Against Sun Damage—and Skin Cancer—According to a New Study, https://www.allure.com/story/cbd-sun-protection-skin-cancer-study
37 Topical nanoencapsulated cannabidiol cream as an innovative strategy combating UV-A– induced nuclear and mitochondrial DNA injury: A pilot randomized clinical study, https://www.jaad.org/article/S0190-9622(24)02490-3/fulltext)
38 Attenuation of allergic contact dermatitis through the endocannabinoid system. Science 2007, https://pubmed.ncbi.nlm.nih.gov/17556587/
39 Cannabis-Based Products for the Treatment of Skin Inflammatory Diseases: A Timely Review, https://pmc.ncbi.nlm.nih.gov/articles/PMC8878527/
40 The Potential Role of Cannabidiol in Cosmetic Dermatology: A Literature Review, https://doi.org/10.1007/s40257-024-00891-y
41 Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors, https://pubmed.ncbi.nlm.nih.gov/23889474/
13
