CBG (non-psychoactive) A sense of calm, contentment, improved focus, energy, relief from depression and anxiety, reduced muscle discomfort, sharpened cognitive performance, uplift, and bliss.
CBG (non-psychoactive)
A sense of calm, contentment, improved focus, energy, relief from depression and anxiety, reduced muscle discomfort, sharpened cognitive performance, uplift, and bliss.
Over the past few years CBG has become one of the most exciting cannabinoids being studied and experienced for mood bosting, anxiety, chronic pain, sleep and sharpening cognitive function, just to name a few. Remember this is the “feel good” cannabinoid. Plus CBG, and its raw form, CBGA, are both nonpsychoactive.
What makes CBG stand out is the way people actually feel. A 2021 survey of people using predominantly CBG formulations found extraordinary results. Over 70% of participants experienced improvements in energy, attention, thinking and fatigue; many reported calmer mood and less anxiety, and more than half of those with pain saw meaningful relief, often allowing them to reduce or stop other pain medicines. Participants with ADHD, chronic fatigue and IBS also reported substantial improvements, with no adverse effects at all reported. [1]
A 2022 survey found similarly striking results. In the 2022 survey, the most common reasons for trying CBG were anxiety, chronic pain, depression, and sleep problems. A large majority of participants rated their symptoms as “much” or “very much” improved, and many felt that CBG worked better than their conventional medications for pain, mood and sleep, with relatively few and mostly mild side effects such as dry mouth. In 80% of individuals with depression and 78% of individuals with anxiety, people reported preferring CBG over conventional medicine. [2]
Additional studies demonstrated CBG’s potential for neuroprotective effect in toxic and neurodegenerative diseases like multiple sclerosis, Huntington’s disease, and Parkinson’s disease. [3]
The science continues to catch up with peoples’ experiences. In July 2024, the first controlled human clinical trial of CBG found that a single 20 mg oral dose significantly reduced anxiety within an hour, with effects beginning as early as 20 minutes. Participants also performed better on memory tests, including recalling lists of words, suggesting that CBG can simultaneously calm stress and sharpen cognitive performance—something people using it for work, study, or “mental stamina” have been reporting for some time. [4] (I used a lot to keep writing this blog piece and it totally helped!).
Earlier studies also pointed toward antiinflammatory, antibacterial (including activity against drugresistant bacteria), neuroprotective, gutsupportive and bladder/eyehealth benefits. [5]
Mechanistically, CBG appears to interact with cannabinoid receptors in a way that differs from both THC and CBD, and it also targets additional systems involved in inflammation, pain, and mood regulation. Because of this ability to bind to cannabinoid receptors differently than THC and CBD, it is said that this can speed up the relief from anxiety, pain and inflammation as compared to CBD or THC.
Comparing the effects of CBG to CBD (since both are not psychoactive), they are similar, but where CBD is best known as a relaxing, soothing agent helpful for anxiety, pain, and sleep, CBG tends to be more energizing and focusing, while at the same time relaxing. CBG may have a stronger anti-inflammatory effect than CBD and is also being touted for its anti-bacterial (including activity against drug-resistant Staph), neuroprotective, gut health, bladder/eye health, and cognitive benefits.
In conclusion, I want to remind you that most clinical and laboratory studies (including all the studies cited in this piece) still rely on isolated, often synthetically created cannabinoids. As I continue to preach, you want the whole plant, nothing isolated that gets added and nothing synthetically produced. Scientists recognize the superiority of whole plant medicine, describing it as the “entourage effect” - that combination of cannabinoids, terpenes and other plant compounds which synergistically produce a stronger therapeutic or psychoactive effect than any isolate part of the plant could. Just remember, the whole is greater than the sum of its parts. Add to that, Crone Grown’s CBG was grown regeneratively, and you have the perfect medicine.
1 Nano-processed CBG/CBD effect on pain, adult attention deficit hyperactive disorder, irritable bowel syndrome and chronic fatigue syndrome, https://medcraveonline.com/IJCAM/IJCAM-14-00567.pdf
2 Survey of Patients Employing Cannabigerol-Predominant Cannabis Preparations: Perceived Medical Effects, Adverse Events, and Withdrawal Symptoms, https://pubmed.ncbi.nlm.nih.gov/34569849/
3 Echeverry C, Prunell G, Narbondo C, et al. A Comparative In Vitro Study of the Neuroprotective Effect Induced by Cannabidiol, Cannabigerol, and Their Respective Acid Forms: Relevance of the 5-HT1A Receptors. Neurotoxicity Research. 2021;39(2):335-348. https://link.springer.com/article/10.1007/s12640-020-00277-y
See also, Stone NL, England TJ, O’Sullivan SE. Protective Effects of Cannabidivarin and Cannabigerol on Cells of the Blood–Brain Barrier Under Ischemic Conditions. Cannabis and Cannabinoid Research. Published online March 17, 2021. https://www.liebertpub.com/doi/full/10.1089/can.2020.0159
See also, Fleisher-Berkovich S, Ventura Y, Amoyal M, et al. Therapeutic Potential of Phytocannabinoid Cannabigerol for Multiple Sclerosis: Modulation of Microglial Activation In Vitro and In Vivo. Biomolecules. 2023;13(2):376-376. https://pmc.ncbi.nlm.nih.gov/articles/PMC9953076/
See also, Nachnani R, Raup-Konsavage WM, Vrana KE. The Pharmacological Case for Cannabigerol. The Journal of Pharmacology and Experimental Therapeutics. 2021;376(2):204-212. https://pubmed.ncbi.nlm.nih.gov/33168643/
4 Acute effects of cannabigerol on anxiety, stress, and mood: a double-blind, placebo-controlled, crossover, field trial, https://pubmed.ncbi.nlm.nih.gov/39003387/
5 Effect of non‑psychotropic plant‑derived cannabinoids on bladder contractility in mice.” BJU International 115(6), 984–993 (2015). https://journals.sagepub.com/doi/pdf/10.1177/1934578X1501000653
See also, Beneficial effect of the non‑psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease. Biochemical Pharmacology. 2013;85(9):1306–1316. https://pubmed.ncbi.nlm.nih.gov/23415610/
See also, Beneficial Effect of the Non-Psychotropic Plant Cannabinoid Cannabigerol on Experimental Inflammatory Bowel Disease. Biochemical Pharmacology. 2013;85(9):1306-1316. https://www.sciencedirect.com/science/article/abs/pii/S0006295213000543
See also, High Cannabigerol Hemp Extract Moderates Colitis and Modulates the Microbiome in an Inflammatory Bowel Disease Model. Journal of Pharmacology and Experimental Therapeutics. Published online July 15, 2024:JPET-002204. https://www.sciencedirect.com/science/article/pii/S0022356524177737
See also, In Vitro Model of Neuroinflammation: Efficacy of Cannabigerol, a Non-Psychoactive Cannabinoid. International Journal of Molecular Sciences. 2018;19(7):1992. https://www.mdpi.com/1422-0067/19/7/1992
See also, Antioxidant and Neuroprotective Effects Induced by Cannabidiol and Cannabigerol in Rat CTX-TNA2 Astrocytes and Isolated Cortexes. International Journal of Molecular Sciences. 2020;21(10):3575. https://pmc.ncbi.nlm.nih.gov/articles/PMC7279038/
